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Fig. 2. Delay in lobuloalveolar development in Stat6-/-
mice. (A-C) Whole mounts (left panels) and haematoxylin and Eosin
(H&E)-stained sections (right panels) of mammary glands at day 5 (A), 10
(B) and 15 (C) of gestation from wild-type (WT) and
Stat6-/- mice. Images shown are representative of at least
three mice. (D) The number of alveoli was scored in H&E images from
wild-type and Stat6-/- mice at 40x magnification and
the area of the fat pad was measured using ImageJ software. The number of
alveoli/mm2 was calculated and the percentage relative to wild type
was plotted. Student's t-test was performed and *,
** and *** indicate statistical significance with
P values of P<0.001, P=0.011 and
P=0.052, respectively. (E) Proliferation rate was measured by
scoring for Ki-67-positive cells from three different fields at 400x
magnification. Error bars represent s.d. of three independent mice. Student's
t-test was performed and *, ** and
*** indicate statistical significance with P values of
P<0.001, P<0.01 and P<0.003,
respectively.
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