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Fig. 2. Loss-of-function mutations in eIF4G2 result in male
sterility. (A) Diagram of eIF4G2 intron/exon structure and
four strong loss-of-function alleles. Gray, protein coding sequence; black,
untranslated regions; diagonal lines, region encoding conserved middle domain.
(B) Apical third of a wild-type testis. (C) Apical third of a
testis from an eIF4G2 homozygote. (D) Part of testis from
eIF4G2 homozygote. (E) Part of testis from eIF4G2
homozygote carrying a single copy of the genomic rescue transgene.
eIF4G2 mutant flies were
eIF4G2BR21-37/eIF4G2Z3-3283. Scale bars: 100
µm.