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Figure 3


Fig. 3. Vascular phenotypes in the adult Egfl7-knockout mouse. (A-H) Fluorescent angiography (A-D) and CD31 fluorescent staining (E-H) in the retinas of multiple pairs of Egfl7+/+ (A,B,E,F) and Egfl7-/- (C,D,G,H) littermates. (I-L) High-magnification views of aberrant structures in the Egfl7-/- retinas. L is a z-section showing two juxtaposed vessels. Blue, DAPI (I-L, nuclear marker); green, CD31 (I-L); red, collagen IV (K,L only, vascular basement membrane marker). (M-P) CD31 staining on 50 µm-thick sections of peritonea (M,N) and kidney (O,P) from Egfl7+/+ (M,O) and Egfl7-/- (N,P) littermates. Arrowhead, tortuous vessels; red arrows, knots formed by multiple vessels; yellow arrows, vessels of similar diameter running close to each other; asterisks, vascular lumen. The actual size represented by the width of the panel: 1.2 mm (A-D); 330 µm (E-H); 88 µm (I-K); 25 µm (L); 275 µm (M-P).





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