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Fig. 4. EGFL7 regulates the collective migration of ECs, but not the movement of
individual ECs. (A,B) Live imaging at days 4-7 of cultured
mouse aortic rings isolated from Egfl7+/+ (A) and
Egfl7-/- (B) littermates. Colored arrowheads track
individual sprouts over time. (C,D) Quantification of sprout
length (C) and sprout extension velocity (D) on cultured aortic rings isolated
from the Egfl7+/+ (blue bars) and
Egfl7-/- (red bars) littermates. (E) Transwell
migration assay performed on fibronectin- or EGFL7-coated inserts using ECs
isolated from four pairs Egfl7+/+ and
Egfl7-/- littermates. Migration efficiency was compared
between Egfl7-/- (ko) and Egfl7+/+
(wt) samples and the ratios plotted. (F) Migration velocity of
individual HUVECs on fibronectin (FN), EGFL7, or combined substrate. The
actual size represented by the width of the panel: 1.09 mm (A); 0.73 mm
(B).
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