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Fig. 6. Plexin A2 and plexin D1 are required for class 3 semaphorin-mediated
cleft formation. (A) SMG cleft formation was reduced in the SMG ex
vivo cultures treated with antisense ODNs against plexin A2 or plexin D1 for
48 hours. No effects were observed in the SMG explants dissected from knockout
mouse mutants of plexin A3 or plexin A4, or in the SMG explants treated with
antisense ODNs against other plexins. Representative explants are shown in
a and the summary of five independent experiments is shown as a bar
graph in b. Paired t-test: *, P<0.05
while compared with the controls. (B) SMG cleft formation promoted by
Sema3A in the SMG co-cultures was partially abolished by the treatment of
antisense ODNs against plexin A2 or plexin D1, but not by sense ODNs.
Representative photographs were taken from 24-hour co-cultures (a). A
summary of seven independent experiments is shown in b. Scale bars: 100
µm. AS, antisense ODNs; KO, knockout mutants; S, sense ODNs.
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