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Fig. 6. Histological analysis of tumours. Twenty-six weeks after DMBA
treatment of Tam-injected mice, epidermal and melanocytic tumours were
excised, fixed in parrafin, sectioned and stained with Haematoxylin-Eosin for
histological analysis. (A) Representative section from a moderately
differentiated squamous cell carcinoma. (B) An invasive carcinoma
amongst muscle tissue. Note the irregular, elongated cell morphology and the
keratin pearl (arrow). (C,D) Large melanocytic tumours invading
deeply into the muscle and adipocyte layers of the dermis. (E) Section
of a locally invasive squamous cell carcinoma infiltrated by melanocytes.
Black arrow, a keratin pearl; yellow arrow, melanocytes. (F) Section of
a lymph node from a DMBA-treated Tam-injected animal. Yellow arrows,
representative melanocytes. Scale bar: 100 µm in A,B; 240 µm in C; 50
µm in E; 100 µm in F.
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