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Figure 7


Fig. 7. Effect of TGFß-blocking antibody on Tgfbi, Col1a2 and Ctgf expression and lung bud formation. Expression of Tgfbi (B) Col1a2 (D) is noticeably decreased in WT mouse foreguts treated with a pan-specific TGFß-blocking antibody (TAb, asterisks) when compared with foreguts cultured in control medium (A,C, arrowheads). Culturing Raldh2-/- foregut in TAb (F, asterisk) prevents the high-level Ctgf expression typically seen in the untreated Raldh2-/- foregut (E, arrowheads). Lung bud formation in WT foreguts is not affected by the treatment with TAb (B,D). Panels to the right are the corresponding enhanced-contrast images of the explants in B and D. Lu, lung; Ctr, control. Scale bar: 300 µm in B.





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