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Figure 3


Fig. 3. Rib and sternal abnormalities in the Hox5, Hox6 and Hox9 paralogous mutants. (A) Individual skeletal elements, dissected with ribs attached, from the upper thoracic region of Hox5 paralogous mutant, wild-type and Hox6 paralogous mutant mice. The first column shows the first through eighth thoracic elements from a Hox5 mutant mouse (the ventral ribs on T2 in this animal are incompletely formed). The second column depicts the same elements from a wild-type control mouse. The elements in the third column are from a Hox6 mutant (in this mouse, T3 was fused with T4, and so appears incompletely formed). Red arrows denote the rib angle of control T1 and the phenotypic similarity in Hox6 mutant T2 through T4. (B) Individual skeletal elements, with ribs attached, from the thoracic and lumbar regions of a Hox9 paralogous mutant mouse (right column) are compared with those of a wild-type control (left column).





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