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Fig. 6. Schematic representation of paralogous Hox axial skeleton
phenotypes. Somite-derived, primaxial skeletal elements that exhibit
anterior homeotic transformations in paralogous mutants are in red. Lateral
plate-derived structures affected in paralogous mutants are in blue. Note that
Hox5, Hox6 and Hox9 mutant phenotypes are offset in their AP
extent for defects in the somite-derived (red) and lateral plate-derived
(blue) skeleton. The yellow shading highlights somite-derived AP regions that
are affected in adjacent paralogous mutant groups. In each case, the
overlapping regions of phenotype display distinct vertebral morphologies for
each paralogous mutant. The green asterisks in the Hox9 mutant
reflect the posterior shift of the axial skeleton. Mice normally possess 28-30
caudal vertebrae. Only 15 are represented here for simplicity. Despite changes
in the number of caudal vertebrae in Hox9 and Hox11
paralogous mutants, the same average total numbers of vertebrae are present in
all of the paralogous mutants depicted in this diagram, and are the same as in
control animals.
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