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Figure 4


Fig. 4. Inhibition of Fgf8 signaling disrupts pillar cell development. (A) A control cochlear explant that was treated with a function-blocking antibody directed against Fgf5. Stereocilia and cell boundaries are labeled with phalloidin (green) and PCs with anti-p75ntr (red). IHCs and first row OHCs are indicated. (B) Cochlear explant treated with a function-blocking antibody that binds to Fgf8 (labeling as in B). (C) ITO distances for control (anti-Fgf5) and anti-Fgf8-treated explants at basal and midbasal regions of the cochlear duct. *, P<0.001. Scale bar: 20 µm.





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