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Fig. 11. Genetic interaction between drl and Wnt5 during MB
development in Drosophila. Different genotypes were assessed for
the production of a drl-like phenotype. MB morphology was assessed
using the anti-FASII antibody. These results indicate that reduced expression
of lio+/drl+ associated with overexpression of
Wnt5+ gradually leads to a drl-like phenotype.
lio/+, lio2 GAL4-c739/+. 1 UAS, GAL4-c739/+;
UAS-Wnt5+/+. 2 UAS, GAL4-c739/UAS-Wnt5+;
UAS-Wnt5+/+. lio/1 UAS, lio2 GAL4-c739/+;
UAS-Wnt5+/+. lio/2 UAS, lio2
GAL4-c739/UAS-Wnt5+; UAS-Wnt5+/+. lio/drl,
lio2 GAL4-c739/drlR343. n, the number
of brains analyzed. +, wild-type; +/-, moderate midline crossing; -, complete
midline crossing.