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First published online August 10, 2007

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PCP pathway directs border cell manoeuvres

Directed cell migration is another essential feature of morphogenesis. But, although the migration of single cells is well characterised, less is known about the coordinated movement of groups of cells. Now, Bastock and Strutt report that the PCP pathway coordinates cell migration during Drosophila oogenesis (see p. 3055). During this process, motile epithelial border cells detach from the anterior of the developing egg chamber and migrate towards the oocyte, carrying two non-motile polar follicle cells with them. By examining egg chambers from flies carrying mutations in the PCP pathway proteins Frizzled, Strabismus and Dishevelled, the researchers show that the pathway acts in the border cells and the polar follicle cells to promote migration. Other experiments lead them to propose that the PCP pathway mediates communication between motile and non-motile cells and promotes the production of the actin-rich structures that are required for efficient, coordinated migration.

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Related articles in Development:

The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis

Rebecca Bastock and David Strutt
Development 2007 134: 3055-3064. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?