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Fig. 3. Suppression of mesoderm in Bmpr1a mutant mouse embryos.
(A,B) At 6.5 dpc, Fgf8 is expressed in the posterior
epiblast and visceral endoderm of controls, but is lost from the posterior
epiblast of Bmpr1a mutant embryos (n=5). (C-F)
eomesodermin and brachyury (T) are expressed at 6.5 dpc in the
posterior epiblast and extra-embryonic ectoderm of controls, but in
Bmpr1a-/- embryos their expression is lost from the
posterior epiblast and is downregulated in the extra-embryonic ectoderm
(n=9 and n=4). (G-J) Nodal and
Cripto are expressed in the posterior epiblast at 6.5 dpc in
controls, but are lost in Bmpr1a mutant embryos (n=5 and
n=4, respectively). (K,L) At 6.5 dpc, Wnt3 is
expressed in the posterior epiblast and posterior visceral endoderm of the
control but is strongly downregulated in Bmpr1a-/- embryos
(n=4). All are lateral views, anterior to the left.
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