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Fig. 3. Marker gene expression in 13.5 dpc mouse gonads. Urogenital ridge
tissue samples were dissected from wild-type mouse embryos. (A)
Expression of the pre-meiotic marker Stra8 is absent in male (M,
left) but present in female (F, right) 13.5 dpc mouse urogenital ridge
samples. Only germ cells, just prior to entry into meiosis, express this
marker gene and higher expression is seen in germ cells located at the
anterior (top) end of the gonad. (B) Expression of the pluripotency
marker Pou5f1 (Oct4) in male and female 13.5 dpc mouse
urogenital ridge samples. Only premeiotic germ cells express this gene at this
stage of development. Staining highlights the clustering of germ cells in the
male sample in testis cord structures and the dispersal of germ cells in the
female sample. Germ cells are present throughout the length of the female
gonad, but Pou5f1 expression has been downregulated at the anterior
(top) end at this stage (see text). g, gonad; m, mesonephros.
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