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Fig. 8. Genetic interactions in the V2 interneuron lineage. Red arrows
represent positive intracellular interactions that we demonstrated in the
present study, except for Foxn4 
(?) Dll4, which is speculative. Black
arrows denote speculative interactions proposed in the present study. Blue
arrows depict interactions demonstrated in previous studies (see below). The
dashed red line represents the proposed intercellular Dll4/Notch1 interaction
between sibling V2 progenitors, which results in Notch1 being activated
(yellow star) in the cells that develop subsequently as V2b INs. The grey
arrow signifies the requirement of Mash1 for proper V2b development
(Li et al., 2005); this role
of Mash1 is ill-defined (see Discussion). Mash1 is sufficient (in chick) but
not necessary (in mice) for Dll4 upregulation (see Discussion). This
diagram incorporates observations from a number of studies including the
present one: Karunaratne et al.
(Karunaratne et al., 2002)
demonstrated reciprocal activation of Gata2 and Gata3 and repression of Chx10
by Gata2; Muroyama et al. (Muroyama et
al., 2005) showed that Scl induces Gata2 and Gata3 and represses
Chx10 in chick, and that Gata3 is abolished and Gata2 severely
reduced in Scl-null mice; Li et al.
(Li et al., 2005) showed that
Mash1 expression is abolished in Foxn4-null mice.
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