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Figure 1


Fig. 1. Craniofacial defects in Sox3 null mice. (A) Wild-type mouse. (B) Sox3 null mouse with teeth overgrowth and vibrissae paralysis on the left side. (C-H) Skeletal preparation of wild-type (C) and Sox3 null (D) newborns. Higher magnification of the middle ear in a control (E) and mutant (F), where the tympanic ring and distal part of the styloid bone are absent and the stapes and distal part of the malleus are malformed. Magnification of the hyoid bone in wild-type (G) and mutant (H) newborn with abnormal orientation of the lesser horn (asterisk) on the left side. (I) Statistical analysis of the craniofacial skeletal defects in Sox3 null mice (n=14). I, incus; M, malleus; Sp, stapes; St, styloid process; Tr, tympanic ring.





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