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Figure 8


Fig. 8. Ncc migration defects in Sox3; Fgfr1 double mutants. (A) Migration defects were analysed at 9.5 dpc by CrabpI in situ hybridisation. Mouse embryos were littermates obtained from Sox3+/- females mated with Fgfr1n7/+ males. Introduction of the hypomorphic Fgfr1 allele increases the penetrance of the ncc defects on the Sox3 mutant background. (Note: the penetrance of the Sox3 null phenotype is reduced in this cross, perhaps due to the introduction of the different background on which the Fgfr1 mutation is maintained, but the sample size is also small.) (B-E) CrabpI in situ hybridisation at 9.5 dpc on (B) wild-type, (C) Sox3 null, (D) Sox3+/-; Fgfr1n7/+ and (E) Sox3 null; Fgfr1n7/+ embryos showing increasing severity of PA2 defects in double mutants. Insets: PA2 domain magnification.





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