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Fig. 1. Division of the chick optic vesicle into a NR and RPE domain at stage
10. Schematic (above) illustrates the location of the sections in the
temporal part of the optic vesicle at stage 10/11. (A-F) RPE
development. (A) At stage 10, Otx2 expression weakens in the distal
region of the optic vesicle, the presumptive NR (arrowheads). (B) At stage 13,
Otx2 transcripts are abundant in the presumptive RPE (arrows). (C) At
stage 10, Mitf expression is downregulated in the distal region of
the optic vesicle (arrowheads). (D) Mitf expression is observed in
the presumptive RPE at stage 13 (arrows). (E) MMP115 expression is
not observed in the optic vesicle at stage 11 (arrows). (F) The first
MMP115 transcripts appear in the presumptive RPE at stage 13
(arrows). (G-L) NR development. (G) Rx expression is
downregulated in the presumptive RPE at stage 10 (arrows). (H) Rx
expression is restricted to the distal region of the optic vesicle, the
presumptive NR at stage 13 (arrowheads). (I) Parallel section of the optic
vesicle shown in C. At stage 10, Chx10 expression is detected in the
distal region of the optic vesicle (arrowheads), in the region where
Mitf expression weakens. (J) Strong Chx10 expression is
detected in the distal region, the presumptive NR at stage 13 (arrowheads).
(K) Fgf8 expression is not detected in the optic vesicle at stage 10
(arrowheads). (L) At stage 13, Fgf8 expression is observed in the
distal region of the optic vesicle, just beneath the forming lens placode.
Note that in all panels at stage 10/11, the temporal region of the optic
vesicle is shown. LP, lens placode.
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