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Fig. 3. Brdt mutant epididymal sperm are abnormal. (A)
Morphology of epididymis from controls and homozygous mutants showing that
very few sperm are present in the epididymis of the
Brdt
BD1/BD1
mutant mice. (B) Light microscopy showing epididymal sperm of wild-type
and
BrdtBD1/BD1
mutant mice. The photomicrographs show the variations of the abnormalities in
the mutants, which occur throughout the sperm, including in the sperm head,
mid-piece (M) and tail. (C) Electron microscopy of sperm reveals
variation in the extent of nuclear condensation, as reflected by regions of
reduced electron density and also by a failure of the acrosome to form
normally. Residual cytoplasm, which should have been discarded as the residual
body, is seen and it contains aberrant mitochondria. Magnifications in C: WT,
x13,000; mutant, upper right, x8,300; lower left, x10,000;
lower right, x8,300. A, acrosome; N, nucleus; M, midpiece. Scale bar: 5
µm.
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