|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 4. Transcriptome analysis in K14-Gata3-/- HF.
(A-F) Schematic of HF (A) and Gata3 expression in innermost layers of
IRS at P11 (B). Fresh-frozen skin sections of P11 wt (C,D) and
K14-Gata3-/- (E,F) before (C,E) and after (D,F) collecting
HF tissue by laser-capture. RNA from the captured tissue was used for
microarray analysis. DP, dermal papilla; He, Henle's layer of IRS; HS, hair
shaft; Hu+Ci, Huxley's layer and cuticle of IRS; Me, medulla; ORS, outer root
sheath. (G,H) Full mouse genome transcriptome analysis of
laser-captured, K14-Gata3-/- and wt HFs. (G) Pie chart of
significantly over-represented biological processes in
K14-Gata3-/- as compared with wt HFs. (H) Significant gene
expression changes in the K14-Gata3-/- as compared with wt
mouse HFs (for an extensive overview, see Table S1 in the supplementary
material). FC, fold change; P=P-value for two-tail analysis of
variance.
|
