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Figure 7


Fig. 7. Skin localization of differentiation and proliferation markers in control and K14-Gata3-/- skin. (A-D) Normal staining of the late-stage differentiation marker loricrin at P1 (A,B) and 5 months (C,D). (E,F) Normal staining of the differentiation marker K10 at P4. (G,H) K10 expression at P26; note the cyst-like HFs in K14-Gata3-/-. (I-M) Double-labelling of K10 (red) and K6 (green) at P11 (I-K) and at 5 months (L,M). There are clearly separated expression domains in the wt (I), but in K14-Gata3-/- K6 expression extends more distally (J); the arrow in K indicates a double-labelled (yellow) cell present in the K14-Gata3-/-. Scale bar in A: 200 µm for A-H; 150 µm for I,J,L,M; 10 µm for K.





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