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Fig. 8. Expression pattern of signalling molecules in HFs in the absence of
Gata3. (A,B) Reduced expression levels of Wnt5a in
K14-Gata3-/- HFs (B) as compared with wt littermate
controls (A). (C,D) Increased Wnt11 expression in the
K14-Gata3-/- outer HF layer (D) as compared with wt
controls (C) at P11. (E,F) Stronger nuclear ß-catenin
staining in K14-Gata3-/- HFs in the matrix and in the
distal part of the HF (F) as compared with control (E) at P11.
(G,H) Decrease in Gli1 expression levels, particularly
in the region of the dermal papilla in P7 K14-Gata3-/- HFs
(H) as compared with controls (G). (I,J) Higher expression
levels of Notch1 at P11 in the K14-Gata3-/- HF
(J) as compared with wt (I). Scale bar in A: 150 µm for A-D,I,J; 100 µm
for E,F; 200 µm for G,H.
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