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Fig. 7. Impaired tectum and cerebellum development in Lmx1bw
CKO mice. (A,B) Dorsal view of the mid/hindbrain region of
intact P0 brains. A similar reduction in the size and displaced location of
the tectum and cerebellum (Cb) was observed to that described for the
conventional Lmx1b-/- mice (see
Fig. 2A,B). (C,D)
Parasagittal Nissl-stained section of P0 brains. Similar defects were seen to
those found in the conditional knockout mice (see
Fig. 2C,D). (E,F)
Double immunostaining of BRN3b and calbindin, marking the tectum and
cerebellar Purkinje cells, respectively, showing the same staining patterns as
described for the conventional knockout mice (see
Fig. 2E,F). cp, choroids
plexus; Hy, hypothalamus; IC, inferior colliculus; PT, pretectal region; SC,
superior colliculus; Th, thalamus. Scale bars: C,D, 700 µm; E,F, 250
µm.
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