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Figure 2


Fig. 2. Dorsal interneuron development in Lhx1 and Lhx5 single mutants. (A-C) Inactivation of either Lhx1 or Lhx5 does not alter the specification of dILA interneurons. dILA interneurons express Pax2 and Lhx5 in Lhx1-/- embryos (B), or express Pax2 and Lhx1 in Lhx5-/- embryos (C). (D-I) In both Lhx1 and Lhx5 single mutants, dILA cells retain their GABAergic identity, and express Viaat (D-F) and Gad1 (G-I). (J-O) Lhx1 expression is unchanged in the cord of Lhx5-/- mutants. There is no upregulation of Lhx1 mRNA at early (not shown) or later (arrows in J,L) stages. There is also no change in Lhx5 expression in the cord of Lhx1-/- mutants at E12.5 (arrows in M,N).





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