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Figure 4


Fig. 4. Early inhibitory-interneuron cell types are correctly specified in the Lhx1; Lhx5 double-knockout cord. (A-H) Cross sections through E11.5 wild-type (wt) and Lhx1;Lhx5 mutant (DKO) cord at forelimb level. (A,B) In the DKO cord, expression of Brn3a is unchanged in dI1-dI3 (arrow in B) and in dI5 (arrowhead) neurons. (C,D) Isl1 expression in dI3 neurons (arrowhead) is also unchanged. (E,F) Lbx1 expression in dI4-dI6 neurons is normal in the DKO cord (F, arrowhead). (G,H) Pax2, which marks dI4 inhibitory neurons (arrowhead) as well as the more ventrally located dI6, V0 and V1 inhibitory neurons, is expressed in a normal pattern in the DKO cord (H). A small decrease in the level of Pax2 expression was observed.





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