spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 6


Fig. 6. Lhx1 and Lhx5 regulate late aspects of development in Pax2 inhibitory interneurons. (A-D) Dorsal horn quadrants showing the downregulation of Pax2 in dILA neurons. This downregulation begins at E12.5 in DKO animals (asterisk, B) and is more pronounced at E14.5 (asterisk, D). (E-H)Lmx1b+ dILB neurons are specified normally and settle in the superficial dorsal horn in DKO animals at similar stages to wild type. (I-L) VGluT2 is not upregulated in the superficial dorsal horn (arrows) indicating that GABAergic Pax2+ cells do not adopt a dILB glutamatergic phenotype in the DKO cord. (M,N) E17.5 DKO animals exhibit a loss of Pax2 expression both dorsally and ventrally at E17.5. (O) Cell counts of Pax2+ and Lmx1b+ cells at E14.5 show a >60% reduction in the number of dorsal Pax2+ cells without any increase in the number of Lmx1b+ dILB cells.





Right arrow Return to article