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Fig. 6. Pregnancies in Dprp-null mice are vulnerable to maternal
hypoxia. (A) Determination of the ontogeny of decidual PRL family
expression by RT-PCR analysis. (B) Exposure of pregnant females to
hypobaric hypoxia (equivalent of 11% oxygen) from days 5.5 to 11.5 of
gestation. After day 11.5, the animals were returned to ambient conditions and
examined on day 17.5 of gestation. (C,D) Gross appearance of a
representative uterus from pregnant wild-type (+/+) and Dprp-null
(-/-) mice exposed to hypoxia. (E) Quantification of pregnancy outcomes
in wild-type (+/+; n=19) and Dprp-null mutant (-/-;
n=10) mice exposed to hypoxia. Numbers of healthy and dying/resorbed
conceptuses are significantly different between wild-type and
Dprp-null mutant pregnancies; P<0.01. Note that unlike
wild-type pregnant female mice, Dprp-null pregnant female mice do not
adapt effectively to hypoxia.
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