QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online December 21, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Indian hedgehog signalling given a lIFT

Cilia are present on most cells of the body and their formation depends on intraflagellar transport (IFT). Mutations that affect IFT lead to altered sonic hedgehog (Shh) signalling, and consequently to limb and neural tube patterning defects in mice. Now, on p. 307, Bradley Yoder and co-workers reveal for the first time that IFT and therefore cilia are also required for normal Indian hedgehog (Ihh) signalling. They made their discovery using a conditional allele of an IFT protein, IFT88/polaris, to disrupt cilia and to investigate the effects on mouse limb development. Although cilia disruption in the ectoderm produces no phenotype, disruption in the mesenchyme results in polydactyly, a loss of anteroposterior digit patterning and a shortening of the proximodistal axis of the limb. Their results show that the digit-patterning phenotypes are associated with disrupted Shh activity. The limb outgrowth defects, however, are due to abrogated Ihh signalling during endochondral bone formation, the first evidence that IFT and normal cilia functioning are required for Ihh signalling.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Intraflagellar transport is essential for endochondral bone formation

Courtney J. Haycraft, Qihong Zhang, Buer Song, Walker S. Jackson, Peter J. Detloff, Rosa Serra, and Bradley K. Yoder
Development 2007 134: 307-316. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?