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Figure 1


Fig. 1. Fgf3 alleles and adult phenotypes. (A) Depiction of wild-type (Fgf3+), original (Fgf3neo) and newly targeted (Fgf3{Delta}2) Fgf3 alleles. Solid lines, mouse genomic Fgf3 DNA; open boxes, untranslated regions; solid boxes, protein-coding regions; gray box, MC1Neo cassette. (B) Genotypes at weaning of Fgf3+/neo and Fgf3+/{Delta}2 intercrosses. Numbers and percentage of total (in parentheses) for wild-type (+/+), heterozygous (+/neo or +/{Delta}2) and homozygous (neo/neo or {Delta}2/{Delta}2; photographs to the right) offspring are shown. (C) Auditory brainstem response (ABR) thresholds of Fgf3+/{Delta}2 intercross offspring. Average thresholds (in decibels sound pressure level) for left (L, blue) and right (R, red) ears of +/+ (n=7) and +/{Delta}2 (n=12) animals are shown as boxes; bars indicate one standard deviation. Homozygous mutant ({Delta}2/{Delta}2) ABR measurements are presented as connected circles (left, blue; right, red) for individual animals, with numbers in parentheses indicating the total number of mutant animals with the specified phenotype. Low (D,E) and high (D',E') magnification views of Hematoxylin and Eosin-stained mid-modiolar sections of Fgf3+/{Delta}2 (hearing, D,D') and Fgf3{Delta}2/{Delta}2 (deaf, E,E') ears. oC, organ of Corti; sv, stria vascularis; tm, tectorial membrane. Scale bars: 50 µm.





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