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Fig. 2. Regulated levels of Ttk specify fusion cell identity.
(A,B) Stage 15 embryos labelled to highlight Esg-positive fusion
cells (arrows in A). Tracheal overexpression of ttk (B) blocks fusion
fate acquisition (arrows) and branch fusions. (C) Late-stage embryo
overexpressing ttk specifically in fusion cells, which also leads to
a lack of branch fusion. (D-F') Details of one or two tracheal
metameres focused at the lateral trunk (LT; D,D'), dorsal trunk (DT;
E,E') or dorsal branches (DBs; F,F'). Dys-positive fusion cells
(arrows) show lower levels of Ttk69 (in greyscale in panels D',E'
and F') when compared with the neighbouring tracheal cells.
(G,G') Two tracheal metameres focused at the LT. All extra
fusion cells (arrows) in N loss-of-function conditions show lower levels of
Ttk69 (in greyscale in G'). (H,H') Four tracheal
metameres focused at the DT. No cells show low levels of Ttk69 (in greyscale
in H') when N is constitutively active. All panels show projections of
confocal sections of laterally viewed embryos.
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