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Fig. 5. Genetic pathways for germ cell apoptosis in C. elegans.
(A) The genetic pathway for constitutive germ cell apoptosis. The genes
lin-35, dpl-1, efl-2 and, most likely, efl-1, promote
constitutive germ cell apoptosis by blocking the function of the
anti-apoptotic gene ced-9 or by enhancing the function of the
pro-apoptotic genes ced-4 and ced-3, respectively.
Furthermore, a lin-35, dpl-1, efl-1 and efl-2-independent
pathway most likely acts in parallel to lin-35, dpl-1, efl-1 and
efl-2 to promote constitutive germ cell apoptosis. Solid lines
represent confirmed genetic interactions. (B) The genetic pathway for
DNA damage-induced germ cell apoptosis. lin-35, dpl-1 and
efl-2 function downstream of or in parallel to cep-1 to
cause DNA damage-induced germ cell apoptosis by controlling the expression of
unknown target genes. See text for details.
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