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Figure 6


Fig. 6. A comparison of PR+/-;{Delta}N89ß-catenin and PR-/-;{Delta}N89ß-catenin glands. (A,C,E) PR+/-;{Delta}N89ß-catenin; (B,D,F) PR-/-;{Delta}N89ß-catenin. Hematoxylin and Eosin staining (A,B) shows that {Delta}N89ß-catenin induces bilayered, secretion-filled structures. Note that alveolar lumen diameters are significantly larger in PR-/-;{Delta}N89ß-catenin glands. Functional alveolar differentiation is demonstrated by immunohistochemistry for casein expression (C,D) and Oil Red O staining (E,F) to detect lipid droplets in alveoli. (G) Average alveolar luminal area in PR+/-;{Delta}N89ß-catenin (gray) and PR-/-;{Delta}N89ß-catenin (black) glands. Scale bars: 50 µm.





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