DEV02873 Supplementary Material

Files in this Data Supplement:

• Supplemental Figure S1 -

  Fig. S1. Controls for clone induction dynamics. lacZ staining of embryos after 4OTM injection during gestation. (A) lacZ-positive cell distribution across the limbs of an E10.5 embryo after a 1 mg 4OTM injection at E9.5. (B) Example of a spontaneous clone found in a limb of an E13.5 embryo (arrow). (C-E) Frequency of clones observed at different times after low dose 4OTM injections (2.5 μg/g body weight).