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Figure 6


Fig. 6. Decreased Tgf-ß signaling in the septating OFT of Ltbp1L mutants. (A) Quantification of Tgf-ß1, Tgf-ß2, Tgf-ß3, Ltbp3, Ltbp4 and c-Myc expression by Q-RT-PCR, using cDNA isolated from three sets of E11.5 control (blue) and knockout (KO, burgundy) hearts. (B) Distribution of pSmad2 in E11.5 control (upper) and KO (lower) OFTs. Framed parts of the outflow tracts (OFTs) are magnified to show cardiac neural crest cell (CNCC)-specific attenuation of Smad2 phosphorylation. (C) Ctgf expression in E11.5 control and KO hearts estimated by in situ hybridization on sections taken at levels (a, b, c) indicated in the diagram and (D) semi-quantitative RT-PCR on cDNA isolated from E11.5 hearts.





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