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Fig. 5. npc2a and npc2b act redundantly in regulating sterol
homeostasis in Drosophila. Filipin staining patterns of
third-instar larval tracheas (A) and brains (B) in different
genetic backgrounds. (A) npc2a and npc2b act redundantly in
regulating sterol homeostasis in trachea. A small number of filipin-stained
particles of sterol accumulation (arrow) was found in npc2a animals.
By contrast, there was no sterol accumulation phenotype in npc2b
mutants or in wild-type animals (not shown). However, massive sterol
accumulation (arrow) was found in npc1a animals as well as npc2a;
npc2b double mutants. (B) In brains, the punctated filipin-stained
pattern (arrows) was found in both npc2a single and npc2a;
npc2b double mutants but not wild type or npc2b single
mutants.
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