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Figure 3


Fig. 3. FGF9 requires VEGF signaling for the formation and maintenance of the lung capillary network. (A-D) Incubation of E12.5 lung explants for 48 hours with 2.5 ng/µl FGF9 stimulates robust capillary formation (B) compared with untreated lung (A). The VEGFR inhibitor SU5416 (45 µM) eliminates the formation and survival of vessels (C). FGF9 is unable to stimulate growth of new distal vessels in the presence of SU5416 (D) but can partially rescue blood vessel survival in very proximal regions. (E-H) FGF9 stimulates luminal dilation of the epithelial tubules (F). Branching morphogenesis appears comparable to controls in SU5416-treated explants (G). In contrast to capillary development, FGF9-induced luminal dilation is not affected by SU5416 (H). Scale bar: 50 µm.





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