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Figure 2


Fig. 2. Development of the trigone. (A) Brightfield/darkfield composite showing a frontal section through an E15 embryo stained for uroplakin (red) to reveal the urothelium, and smooth muscle alpha actin (green) to reveal smooth muscle. Note the absence of muscle surrounding the intramural ureter compared with the extra-mural ureter, which already has a thick smooth coat. (B) The trigone in a newborn mouse showing the intramural ureter crossing the bladder muscle and submucosa. Note the longitudinal muscle fibers surrounding the intramural ureter. (C) The trigone in an adult mouse. (D) The bladder of a newborn mouse showing the deep folds of the lining, and the muscularis mucosa and smooth muscle layers below. (E) Higher magnification of the ureteral tunnel shown in B. (F) High-magnification image of the intramural ureter showing the longitudinal muscle fibers (green). (G) Higher magnification of the region in C showing the position in the trigone where the ureter joins. Note the longitudinal fibers that intercalate with the bladder muscle (yellow arrows). (H) The urethra in a newborn mouse showing the thick muscle coat (green) and smooth urothelial surface (red). Magnification: x50 in A-C; x100 in D,E,G,H; x200 in F.





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