QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online September 28, 2007

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Progesterone and ß-catenin: priming mammary development

The mammary gland undergoes significant postnatal development that is temporally regulated by hormonal signalling. During pregnancy, side branches form from the mammary ductal tree and alveoli develop at their tips; both are lost in progesterone receptor (Pgr)-null mice. To investigate how hormonal and ß-catenin signalling (which also acts in pregnancy-induced mammary differentiation) intersect during postnatal mammary development, Hiremath et al. tested whether a non-degradable form of ß-catenin (MMTV-N89ß-catenin) could rescue the phenotype of Pgr-null mice (see p. 3703). They found that although stabilized ß-catenin rescues alveogenesis at ductal tips, it cannot stimulate alveolar development along the lateral borders of mammary ducts. This, the authors propose, is due to the existence of two ß-catenin-responsive cell populations: one at ductal tips that is intrinsically ß-catenin responsive; the other, a progenitor population, at the lateral ductal borders of virgin glands that requires Pgr signalling to become primed for alveogenesis in response to ß-catenin. These findings advance mammary development research, not least by identifying this novel progenitor population.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

The pattern of ß-catenin responsiveness within the mammary gland is regulated by progesterone receptor

Minoti Hiremath, John P. Lydon, and Pamela Cowin
Development 2007 134: 3703-3712. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?