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Figure 2


Fig. 2. Labeling of early born cortical neurons in wild-type and ApoER2-/- mice at P7 using Tbr1 and Tle4. Immunostaining for Tbr1 (A,B) and in situ hybridization for Tle4 (C,D) on sagittal brain sections revealed the strongest signal in deep cortical layers of wild-type animals (A,C). Similar to the staining for ER81, both markers show a shift in early born neurons towards more superficial regions in the ApoER2 mutant cortex (B,D). Scale bars: 200 µm in A,B; 100 µm in C,D.





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