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Figure 4


Fig. 4. Cux2 and RORbeta staining in wild-type animals and ApoER2 mutants at P7. (A,E) In situ hybridization for RORbeta, a marker of layer IV neurons, showed strong expression in layer IV in sections of wild-type animals (arrow in A). In ApoER2 mutants (E), strongest RORbeta expression was found in superficial portions of the cortex underneath the marginal zone and close to the ventricle (arrows). (B-D,F-H) Double fluorescence in situ hybridization for Cux2 (green) and RORbeta (red) revealed that Cux2 labels mainly layer II-III neurons and only a superficially located subpopulation of layer IV in wild-type animals (B-D). Arrowheads in D point to double-labeled cells. In ApoER2 mutants (F-H), Cux2- and RORbeta-labeled neurons were scattered throughout the cortex with cell accumulations underneath the marginal zone and close to the ventricle (arrows). Arrowheads in H point to double-labeled cells. Scale bars: 200 µm.





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