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Fig. 7. Invasion of the marginal zone in Vldlr mutants.
(A,B) In situ hybridization for Cux2 on sagittal brain
sections through the neocortex of adult wild-type mice (A) showed only few
neurons in layer I, whereas many Cux2-positive cells were found in
the marginal zone of Vldlr-/- mice (B). (C-E)
Sagittal brain sections through adult neocortex stained for NeuN similarly
showed few neurons in wild-type animals (C) and ApoER2 mutants (D),
but numerous cells in Vldlr mutants (E). Scale bars: 100 µm in
A,B; 200 µm in C-E. (F) Stereological estimation of cell numbers in
the marginal zone was performed in four animals of each group.
Vldlr-/- mice showed significantly more neurons
(mean±s.e.m.) in the marginal zone compared with wild-type animals and
ApoER2 mutant mice (P=0.029). No significant difference was
found between wild-type animals and ApoER2 mutants.
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