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Figure 2


Fig. 2. Skeletal abnormalities in Prx1-Hif1{alpha} mutants. (A-C) Alizarin Red and Alcian Blue staining of wild-type (top) and Prx1-Hif1{alpha} (bottom) mouse forelimbs. E18.5 littermates demonstrate severe retardation in limb skeleton formation (A) and joint fusion (B). Autopod skeletons (C) show cartilage formation at the periphery of the forming digits and joint loss in the Prx1-Cre-Hif1{alpha} limb. (D) Histological sections of E13.5 control (top) and Prx1-Cre-Hif1{alpha} (bottom) elbows. In the Prx1-Cre-Hif1{alpha} joint, the presence of apoptotic cells with shrunken cytoplasm and condensed nuclei is observed. (E,F) Histological sections through the digits revealed partial joint cavitation (E) and loss of phalanx (F). (G-I) MicroCT analysis of 21-day-old Prx1-Cre-Hif1{alpha} and WT autopod: dorsal view demonstrates severe retardation in the Prx1-Cre-Hif1{alpha} skeleton including bone deformation, lack of phalanges (bracket), and joint fusion. H and I show dorsal and lateral views, respectively, of digit 3. Yellow arrows indicate fused joints and fused sesamoid bones.





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