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Figure 3


Fig. 3. HIF1{alpha} is necessary for chondrocyte differentiation. (A,B) Histology sections of E13.5 control (top) and Prx1-Cre-Hif1{alpha} (bottom) autopods showing mesenchyme-like morphology of the cells in Prx1-Cre-Hif1{alpha} digits. (B) Higher magnification of the boxed area in A demonstrates lack of interzone formation. (C,D) In situ hybridization for Sox9. (C) Uniform expression of Sox9 in E11.5 mesenchymal condensation; (D) substantial reduction in Sox9 expression in the center of E12.5 Prx1-Cre-Hif1{alpha} digits. (E-H) Serial sections of E13.5 control and Prx1-Hif1{alpha} autopods were hybridized with RNA probes for Sox9 (E), Sox6 (F), collagen type II (Col2a1; G) and aggrecan (H). Yellow arrows indicate the interzone.





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