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First published online October 12, 2007

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Runx oncogenic potential wormed out

Runx transcription factors, the DNA binding of which is enhanced by CBFß, play important roles during development and may act as tumour suppressors and oncogenes. Disentangling what Runx proteins do in mammalian systems, where there are three Runx genes, has proved difficult, so researchers have turned to C. elegans, which has only one Runx homologue rnt-1. On p. 3905, Kagoshima and colleagues report that BRO-1, the worm CBFß homologue, interacts with RNT-1 to promote self-renewal and proliferation of stem cells. They show that bro-1 and rnt-1 deletion mutants both lack some male-specific sensory rays because of failed cell divisions in the stem-cell-like seam cells from which the rays develop. BRO-1 increases the affinity and specificity of RNT-1-DNA interactions, they report, but can also act independently of RNT-1. Finally, co-overexpression of rnt-1 and bro-1 causes seam cell hyperplasia (effectively, a tumour). These new insights into the function of Runx/CBFß in stem cells support the idea that this DNA-binding complex has oncogenic potential.

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The C. elegans CBFß homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal

Hiroshi Kagoshima, Rachael Nimmo, Nicole Saad, Junko Tanaka, Yoshihiro Miwa, Shohei Mitani, Yuji Kohara, and Alison Woollard
Development 2007 134: 3905-3915. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?