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Figure 6


Fig. 6. Disruption of cyclic gene expression in the Fgfr1f/f;T-Cre mutant embryos. (A-H) Comparison of expression of the cyclic genes of the Notch (Lfng), FGF (Spry2, Snail1) and Wnt (Axin2) signaling pathways at stages E8.75 (A-F) and E9.0 (G,H). All genes show dynamic expression in heterozygous Fgfr1f/+;T-Cre control embryos (A,C,E,G). Oscillations in Fgfr1f/f;T-Cre mutant embryos are lost (B,D,F,H). Lateral views are shown for Fgfr1f/+;T-Cre in A,E,G and dorsal views are shown in C. For Fgfr1f/f;T-Cre mutant (B,D,F,H), a lateral view is shown in the left panels, whereas dorsal views are shown in the right panels.





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