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Figure 7


Fig. 7. Summary of the onset of the phenotypes observed in Fgfr1f/f;T-Cre mutant embryos. FGF target genes become downregulated in the posterior PSM of Fgfr1f/f;T-Cre mutant embryos at the 5- to 7-somite stage, followed by the arrest of cyclic gene expression between somites 8 and 10. Normal somites and corresponding vertebrae elements are observed up to somites 10 to 13; however, abnormal skeletal elements derived from paraxial mesoderm posterior to somite 13 were present.





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