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Fig. 7. Summary of the onset of the phenotypes observed in
Fgfr1f/f;T-Cre mutant embryos. FGF target genes become
downregulated in the posterior PSM of Fgfr1f/f;T-Cre
mutant embryos at the 5- to 7-somite stage, followed by the arrest of cyclic
gene expression between somites 8 and 10. Normal somites and corresponding
vertebrae elements are observed up to somites 10 to 13; however, abnormal
skeletal elements derived from paraxial mesoderm posterior to somite 13 were
present.