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Fig. 5. Axonal wiring of GC-D⁺ neurons depends on Npr2 and Sema3f. (A) Whole-mount view of the medial OB of GCD-ITL homozygous mice visualized by X-Gal staining in wild-type (+/+), NP2- ${Delta}$ homozygous (NP2- ${Delta}$ -/-), ${Delta}$ F homozygous ( ${Delta}$ F -/-), and ${Delta}$ B homozygous ( ${Delta}$ B -/-) backgrounds. The innervation pattern in ${Delta}$ B homozygous mice is similar to that in wild type. NP2- ${Delta}$ and ${Delta}$ F homozygous mice have axons that extend not only in the ventral areas, but also in the dorsal and anterior aspects of the MOB where they form ectopic glomeruli (arrows). Several of these glomeruli form in the deeper layers of the MOB (arrows with asterisks). Anterior, left; dorsal up. (B) Whole-mount view of the dorsal OB of GCD-ITL homozygous mice in the same backgrounds as in A. Labeled axons and glomeruli (arrows) are detectable in NP2- ${Delta}$ and ${Delta}$ F homozygous mice in areas that are not occupied in wild-type and ${Delta}$ B homozygous mice. Anterior left, lateral up. (C) Whole-mount view of the lateral OB of GCD-ITL homozygous mice in the same backgrounds as in A and B. As seen medially, ectopic glomeruli (arrows) are observed that reside sometimes in deeper layers (arrows with asterisks). Anterior left, dorsal up. Scale bar: 1000 µm.

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