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Fig. 1. Parvalbumin (PV) and somatostatin (SSN) immunoreactivities in
somatosensory cortex and hippocampus of wild-type and
cD2-/- mice. (A,B) PV neurons are
especially reduced in superficial cortical layers in
cD2-/-. (C,D) Hematoxylin-counterstained
sections show PV interneurons are reduced in the cD2-/-
hippocampus. (E) PV neuron density is reduced in all regions of
cD2-/- cortex (HP>SS1, M1/M2). (F,G) The
relative SSN neuron density distribution is similar in WT and
cD2-/- nulls despite cortex thinning. (H,I)
The density of SSN-immunolabeled neurons is slightly increased in the
hippocampal stratum oriens and dentate of cD2-/-.
(J) The SSN neuron density is unchanged in cD2-/-
mice. (A-D,F-I) 40 µm sections. a, alveus; o, stratum oriens; p, stratum
pyramidale; r, stratum radiatum; l-m, lacunosum moleculare layer; dnt, dentate
gyrus; HP, hippocampus; SS1(bf), primary somatosensory cortex (barrel field
region); M1/M2, primary and secondary motor cortex; WT, wild type.
Mean±s.e.m. densities of PV-IR neurons in the null are expressed as
percentage of control (WT). n=5-8 per genotype per region;
*, P<0.02; **, P<0.001.
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