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Figure 5


Fig. 5. Cdk-inhibitor p27 and cD-Cdk effector retinoblastoma in the MGE of cD2-/- and cD1-/- mice as compared with wild-type littermates. (A-H) At E12.5 (A-D) and E14.5 (E-H), the labeling-intensity of p27 (A,B,E,F) is increased and fewer nuclei label with phosphorylated Rb (pRb) (C,D,G,H) in cD2-/- mice than in the WT. (I-P) The distribution of p27+ cells is reduced specifically in the VZ of cD1-/- (J,N), as compared with WT (I,M). pRb labeling is equivalent in cD1-/- and WT MGE.





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