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Figure 6


Fig. 6. Proliferation markers PH3 and Ki67 are altered in the MGE of cD2-/-, cD1-/- and WT littermates. (A,B,E,F) The numbers of PH3-labeled M-phase nuclei are reduced in both the VZ and SVZ of cD2-/- mice. The distribution of PH3-immunolabeled nuclei is most substantially reduced in cD2-/- in the ventral SVZ. (C,D,G,H) The numbers and distribution of Ki67-immunoreactive nuclei are also reduced in the SVZ of cD2-/- as compared with WT. (I,J) The numbers and distribution of PH3+ nuclei in cD1-/- and WT are identical. (K,L) Distribution of Ki67+ nuclei is similar in WT and cD1-/-. Proliferation in the VZ and SVZ of cD1 nulls is less affected than in cD2-/- mice.





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